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Let’s get into the nitty-gritty of what makes **TNBC** tick. TNBC doesn't express the estrogen receptor (ER), the progesterone receptor (PR), or the human epidermal growth factor receptor 2 (HER2). This lack of these receptors is the hallmark of TNBC. The absence of these receptors means that the cancer cells don't respond to hormone therapies or HER2-targeted therapies, which are effective treatments for other types of breast cancer. This means that treatment strategies have to focus on other targets. Because TNBC lacks these receptors, it often behaves differently. It tends to grow faster and is more likely to spread to other parts of the body. This is why TNBC is often diagnosed at a more advanced stage than other portfolio analysis example high net worth individual 2019 types of breast cancer. TNBC tends to be more common in younger women, and women of African American and Hispanic descent. The exact reasons for this are still being researched, but it is important to be aware of these risk factors. Genetic factors can also play a role in developing TNBC, and certain gene mutations, such as BRCA1 and BRCA2, increase the risk. Genetic testing may be recommended for some patients to assess their risk and guide treatment decisions. TNBC can be further classified into subtypes based on their genetic and molecular characteristics. These subtypes can affect how the cancer responds to treatment and can help guide treatment decisions. This is all changing because of clinical trials and new information.
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