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In addition to HLA matching, **immunosuppressive medications** are commonly used to prevent GVHD. These medications are given to the recipient before and after the transplant to dampen the immune system and reduce the risk of an immune attack. Several different immunosuppressive drugs can be used for GVHD prophylaxis. These include cyclosporine, tacrolimus, methotrexate, and sirolimus. These drugs work through different mechanisms to suppress the immune system. They may be used alone or in combination. The choice of immunosuppressive regimen depends on several factors, including the type of transplant, the HLA match, and the recipient's overall health. Immunosuppressive medications are typically started before the transplant and continued for several months or longer after the transplant. The doses are adjusted based on the patient's response and any side effects. While immunosuppressive medications are effective in preventing GVHD, they also have potential side effects. These include increased risk of infection, kidney damage, and high blood pressure. Therefore, close monitoring is necessary to manage these side effects. Researchers are continually exploring new strategies for GVHD prophylaxis, including novel immunosuppressive drugs and other approaches to modulate the immune system. The goal is to find more effective ways to prevent GVHD while minimizing the side effects of treatment. A combination of careful donor selection and immunosuppressive medications has significantly reduced the incidence and severity of GVHD in recent years.
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