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**Chemotherapy** is a major part of treatment for TNBC, often used before and after surgery to kill cancer cells throughout the body. Unlike some other breast cancers, TNBC doesn't have specific targets for hormone therapies or targeted drugs, so chemotherapy is a go-to. It uses powerful drugs to attack and destroy rapidly dividing cells, including cancer cells. It can be given before surgery (neoadjuvant chemotherapy) to shrink the tumor, making it easier to remove, and after surgery (adjuvant chemotherapy) to kill any remaining cancer cells and prevent recurrence. The specific chemotherapy regimen depends on factors like the stage of the cancer, your overall health, and the treatment goals. Common chemotherapy drugs used for TNBC include **anthracyclines** (like doxorubicin and epirubicin) and **taxanes** (like paclitaxel and docetaxel). These drugs can be used alone or in combination, and your oncologist will create a plan tailored to your needs. The goal of neoadjuvant chemotherapy is not only to shrink the tumor but also to assess how the cancer responds to the treatment. If the tumor shrinks significantly or disappears completely (a pathological complete response, or pCR), it is a positive sign that the treatment is working well, and can mean a better prognosis. Adjuvant chemotherapy is used to lower the risk of the cancer coming back after surgery. It's often recommended for most people with TNBC, regardless of whether they had neoadjuvant therapy. The chemotherapy regimen for adjuvant treatment may be similar to or different from what was used before surgery.
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